![]() It was emphasized this was an emergency adaptation of the intended design for austere environments when no additional epinephrine was available. Hawkins and coauthors published a technique for obtaining multiple additional doses of epinephrine from used, single dose autoinjectors EpiPen and Adrenaclick. The product was launched with the brand name "Auvi-Q" in the United States and "Allerject" in Canada. The new device also has retractable needle and automated voice instructions to assist the users on how to correctly use the autoinjectors. Eventually, they came up with a design that has the shape and size of a smartphone which can be put into a pocket. One brother took an engineering major and the other took a pre-medical track and earned a doctorate degree in pharmaceutical sciences. The brothers split to study different fields with a shared goal to create a new device. They realized the inconveniences of carrying bulky autoinjectors and decided to come up with a new device to address the problems while they were in college. Īnother design of epinephrine autoinjectors was created by two brothers who were also users of epinephrine autoinjectors. The European Medicines Agency conducted a review of the safety of devices then on the market and found several factors that determine whether the devices successfully deliver drug into muscle, including "needle length, the thickness of fat under the skin, the way the auto-injector works (e.g., if it is spring loaded or not), the angle at which the device is placed on the skin and the force used to activate the device as well as how well the user follows the instructions for injection." It found that how well the user was trained was the most important factor determining successful delivery, and requested companies to develop better training materials for doctors and people to whom the devices are prescribed. The cause of unintentional injections has been attributed to design flaws, where the device is mistaken for a pen or the user mistakes which end of the device contains the needle. Unintentional injections are delivered to a finger or thumb around 90% of the time they cause intense pain locally but usually completely resolve. The rate of unintentional injections using these devices is unknown but a 2009 review found that the rate is increasing. People to whom epinephrine autoinjectors are prescribed need to be trained how to use the specific device prescribed. The devices contain a fixed dose of epinephrine and a spring-loaded needle (or, in the case of AuviQ, a CO 2-driven needle) that exits the tip or edge of the device and penetrates the recipient's skin, to deliver the medication via intramuscular injection. Needle exits through a protective barrier when this is pressed against the skin. Later springs back to cover the needle after use. When retracted upward (left) exposes the needle and triggers the latch mechanism. Loaded spring that drives the plunger and the needle (toward the right). Four latch mechanisms that hold the plunger secure. The inner mechanism of an epinephrine autoinjector. A study in rabbits showed that intramuscular epinephrine has decreased effectiveness after it expires that study also recommended that if the drug in an expired device has not started to precipitate (if the solution is not cloudy and has no particles in it) using the expired device is better than no injection at all in an emergency situation. The epinephrine in autoinjectors expires after one year. Minor adverse effects from epinephrine include tremors, anxiety, headaches, and palpitations. The intramuscular route is preferred over subcutaneous administration because the latter may have delayed absorption. It is not clear which are the people who might need a second injection at the outset. ![]() A second dose is needed in 16–35% of episodes with more than two doses rarely required in around 80% of the cases where a second dose is administered, it is by a medical professional. ![]() The injection may be repeated every 5 to 15 minutes if there is insufficient response. When anaphylaxis is suspected, epinephrine solution should be given as soon as possible as an intramuscular injection, in the middle of the outer side of the thigh, which corresponds to the location of the vastus lateralis muscle. ALK Pharma Jext300, adrenaline autoinjector, without its safety coverĮpinephrine autoinjectors are hand-held devices carried by those who have severe allergies the epinephrine delivered by the device is an emergency treatment for anaphylaxis. ![]()
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